寿命/PathPlus™ GPER1/GPR30抗体胞质域多克隆ICC，IHC，WB LS-A1183/50µ；g（1毫克/毫升）/LS-A1183-50-免疫在线蚂蚁淘旗下平台

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商品详细寿命/PathPlus™ GPER1/GPR30抗体胞质域多克隆ICC，IHC，WB LS-A1183/50µ；g（1毫克/毫升）/LS-A1183-50

寿命/PathPlus™ GPER1/GPR30抗体胞质域多克隆ICC，IHC，WB LS-A1183/50µ；g（1毫克/毫升）/LS-A1183-50

商品编号： LS-A1183-50

品牌： lsbio

市场价： ¥8500.00

美元价： 5100.00

产地：美国(厂家直采)

公司：

产品分类：抗辣根过氧化物酶

公司分类： Anti_HRP

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description

G-proteincoupledestrogenreceptor1(GPER1)promotesneuritogenesisindevelopinghippocampalneurons.ItplaysaroleinacuteneuroprotectionagainstNMDA-inducedexcitotoxicneuronaldeathandincreasesfiringactivityandintracellularcalciumoscillationsinluteinizinghormone-releasinghormone(LHRH)neurons.GPER1inhibitsmatureADIpocytedifferentiationandlipidaccumulation,andisinvolvedintherecruitmentofbeta-arrestin2ARRB2attheplasmamembraneinepithelialcells.Italsofunctionsasareceptorforaldosterone,mediatingrapidregulationofvascularcontractibilitythroughthePI3K/ERKsignalingpathway.Finally,itisimplicatedincancerprogression.TheUniProtConsortium.NucleicAcidsRes.47:D506-515(2019);NucleicAcidsRes.2016Jan4;44(D1):D733-45,PMID:26553804

(4)Publication(s)

Target

HumanGPER1/GPR30

SeeAllGPER1/GPR30Antibodies

Host

Rabbit

Reactivity

Human(testedor100%immunogensequenceidentity)

Predicted

Monkey(atleast90%immunogensequenceidentity)

Clonality

Polyclonal

Conjugations

Unconjugated.AlsoavailableconjugatedwithAP,APC,Biotin,FITC,HRP,PE.

Purification

Immunoaffinitypurified

Modifications

Unmodified

Applications

IHC
IHC-Paraffin(15-20µg/ml)
ICC
Westernblot
Applicationstestedforthebaseformofthisproductonly

PerformingIHC?SeeourcompletelineofImmunohistochemistryReagentsincludingantigenretrievalsolutions,blockingagentsABCDetectionKitsandpolymers,biotinylatedsecondaryantibodies,substratesandmore.

FailedApplications

Immunofluorescence

Immunogen

Synthetic16aminoacidpeptidefrom1stcytoplasmicdomainofhumanGPR30.PercentidentitywithotherspeciesbyBLASTanalysis:Human,Gorilla(100%);Marmoset(94%);Monkey,Panda(88%).

BlockingPeptide

LS-E28164-Liquid-50µg-$145.00ImmunizingpeptideusedtogenerateLS-A1183.Usefulforpre-absorptionandneutralizationoftheantibody'santigenbindingsite.

Epitope

CytoplasmicDomain

Specificity

HumanGPR30.BLASTanalysisofthepeptideimmunogenshowednohomologywithotherhumanproteins.

Presentation

PBS,0.1%SodiumAzide

Storage

Aliquotandstoreundilutedat-20°Corbelowforupto1year.Canbestoredundilutedat4°Cforupto1month.Avoidfreeze-thawcycles.

Restrictions

Forresearchuseonly.