蛋白质浏览器 |龙生生物,DNMT3A - LSBio

来自 : 发布时间：2024-04-29

Immunohistochemistry ServicesWork with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies. TCR Screening ServicesTest your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their \"Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use\".Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues. Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development. Worldwide Distributors List - To find your local distributor if you\'re not within the United States.order histories, retained contact details for faster checkout, review submissions, and special promotions.order histories, retained contact details for faster checkout, review submissions, and special promotions. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated Lys-36 of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.Synonyms: DNMT3A, DNA MTase HsaIIIA, DNMT3A2, DNA methyltransferase HsaIIIA, M.HsaIIIAAn essential role for DNA methyltransferase DNMT3B in cancer cell survival. Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR. The Journal of biological chemistry. 2002 277:28176-81. (WB; Human)PubMed:12015329 Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human)PubMed:12406579 DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human)PubMed:12496760 Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. The Journal of biological chemistry. 2006 281:24790-802.PubMed:16766534 SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma. Shikauchi Y, Saiura A, Kubo T, Niwa Y, Yamamoto J, Murase Y, Yoshikawa H. Molecular and cellular biology. 2009 29:1944-58. PubMed:19139273 PMC:PMC2655625 Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Carcinogenesis. 2011 32:1450-8.PubMed:21771726 Epigenetic regulation of motor neuron cell death through DNA methylation. Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:16619-36. PubMed:22090490 PMC:PMC3238138 Related Antibodies: LS-C96546. Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases. Selvakumar T, Gjidoda A, Hovde SL, Henry RW. The Journal of biological chemistry. 2012 287:7039-50. (WB; Human)PubMed:22219193 PMC:PMC3293528 DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O Keefe RJ. JCI insight. 2017 2: (WB; Human)Full Text Article PubMed:28614801 PMC:PMC5470890 Related Antibodies: LS-B7240. Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma. Lee HG, Kim H, Son T, Jeong Y, Kim SU, Dong SM, Park YN, Lee JD, Lee JM, Park JH. Oncotarget. 2016 July;7:41798-41810. (Human)Full Text Article PubMed:27260001 PMC:PMC5173097 Related Antibodies: LS-C167495.Price: 60µl1mg/ml$295.00; 120µl1mg/ml$370.00; 200µl1mg/ml$495.00 Price: 20µl$270.00; 50µl$295.00; 100µl$395.00; 200µl$535.00 Price: 20µl$270.00; 50µl$295.00; 100µl$395.00; 200µl$535.00 Price: 20µl$270.00; 50µl$295.00; 100µl$395.00; 200µl$535.00 If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development. PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).